HMGIC (high mobility group protein isoform I-C)

HMGIC (High mobility group protein isoform I-C)

HMGIY (high mobility group protein (non histone chromosomal) isoform I and Y)

Neuroinflammation in Autism Spectrum Disorders: the Role of High Mobility Group Box 1 Protein

The pathogenesis of autism spectrum disorder (ASD) likely involves genetic and environmental factors, impacting the complex neurodevelopmental and behavioral abnormalities of the disorder. Scientific researches emerging within the past two decades suggest that immune dysfunction and inflammation have pathogenic influences through different mechanisms, all leading to both a chronic state of low ...

High-mobility group protein HMG-I localizes to G/Q- and C-bands of human and mouse chromosomes

Mammalian metaphase chromosomes can be identified by their characteristic banding pattern when stained with Giemsa dye after brief proteolytic digestion. The resulting G-bands are known to contain regions of DNA enriched in A/T residues and to be the principal location for the L1 (or Kpn 1) family of long interspersed repetitive sequences in human chromosomes. Here we report that antibodies rai...

High mobility group protein HMGI-C: a molecular target in solid tumor formation

The high mobility group protein HMGI-C is a non-histone chromosomal protein characterized by its capacity to bind in the narrow minor groove of AT-rich DNA. It is thought to act as a so-called architectural transcription factor and to modulate the expression of target genes through the formation of stereospecific complexes on the regulatory regions of these targets. Towards defining its functio...